JWH-018 is stronger than THC or tetrahydrocannabinol, the key active ingredient in cannabis. A small dose is adequate to induce an intoxicating effect. JWH-018 binds the CB1 receptor 4 instances much more tightly plus the CB2 receptor 10 instances a lot more tightly than THC.JWH-018 is more robust plus more unsafe than cannabis and carries a big ri